DSS-ECALBIO CO.,LTD

Dextran Sulfate Sodium Salt

Introduction

Dextran Sulfate (DSS) is a polyinal ion derivative of glucan, which is formed by the esterization reactions of polycosani and chlorohydrates. The sulphur content is about 17%, which is equivalent to the average of 1.9 sulfate groups in each glucose residue of the glucose molecules.

Specifications: 25g / 100g

DSS IBD Modeling Method

In animal modeling, DSS solution is typically prepared by dissolving DSS in pure water and provided freely for consumption. Occasionally, it is combined with azoxymethane (AOM) for combined modeling purposes. The concentration of DSS for modeling is calculated in weight/volume (W/V). By varying the concentrations of DSS, duration of treatment, and treatment frequencies, both acute and chronic models of inflammatory bowel disease (IBD) can be developed. Generally, acute colitis models are established using higher concentrations of DSS solution and relatively short treatment durations, e.g., 3%-5% DSS in drinking water for 4-7 days. Chronic colitis models, on the other hand, can be established using lower concentrations of DSS with longer treatment durations, e.g., rats may be provided with 1% DSS in drinking water for 120 days.

Notices:
①　This product is non-sterile packaged. If used for cell culture, please pre-treat to remove thermophilic bacteria,

otherwise contamination may occur.
②　For some products, our company can only provide partial information, and we do not guarantee the authority of

the information provided. The above data is for reference only.

Description

DSS has several characteristics:
①　 Aggregates anionic complexes, soluble in water, forming colorless aqueous solutions.
②　 High purity and good stability.
③　 Can be naturally degraded.

Inflammatory bowel disease (IBD) is a chronic, recurrent gastrointestinal infection that increases the risk of intestinal tumor occurrence, mainly including UC and Crohn's disease (CD). Since the first report in 1985 of using dextran sulphate sodium (DSS) to prepare hamster ulcerative colitis model, a large number of studies have shown that the DSS colitis model is similar to human ulcerative colitis. The histological characteristics, clinical manifestations, affected sites, and cytokine proliferation in the DSS colitis model are very similar to human ulcerative colitis (UC). This model has simple modeling conditions and operating methods, low cost, good repeatability, easy to master and promote; the DSS concentration and duration of treatment can be adjusted according to the experimental purpose to establish acute, chronic, and acute-chronic alternate models.

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