Synonyms

Apoptosis regulator BAX, Bcl-2-like protein 4 (Bcl2-L-4), BCL2L4

Background                                                          

Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Cross-Reactivity

Human, Mouse

Applications

WB, Auto WB, IHC-P, ELISA

Isotype

IgG

Purification
Affinity purification

Immunogen

Synthetic peptide derived from human BAX.

Storage conditions:

Store the Antibody at -20℃ and Primary Antibody Dilution Buffer at 4℃ for up to one year. The Primary Antibody Dilution Buffer can be stored at -20℃for lone-term storage, but freeze-thaw may result in slight turbidity and a small amount of insoluble substance.