Synonyms

Apoptosis regulator Bcl-2, BCL2

Background                                                          

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis. It was the first apoptosis regulator identified in any organism. Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. Orthologs (such as Bcl2 in mice) have been identified in numerous mammals for which complete genome data are available.

Cross-Reactivity

Human

Applications

WB, 1:1000

ICC, IF, 1:50-1:200

Isotype

IgG2b

Purification

Protein G purified

Immunogen

Synthetic peptide derived from human Bcl-2.

Storage conditions

Store the Antibody at -20℃ and Primary Antibody Dilution Buffer at 4℃ for up to one year. The Primary Antibody Dilution Buffer can be stored at -20℃for lone-term storage, but freeze-thaw may result in slight turbidity and a small amount of insoluble substance.